Collin T. McManus

This paper introduces a method to reduce air-water interface artifacts in cryo-EM by encapsulating proteins in hydrophilic shells, demonstrating its effectiveness with three protein examples.

This study identifies SCM-1/SCAMP as a key factor maintaining microdomain boundaries in the endosomal system, ensuring proper cargo sorting and preventing microdomain overlap.

This study identifies how XMAP215 interacts with γ-TuRC to promote microtubule nucleation through specific TOG domains and reveals structural insights into their cooperative function.

This paper identifies two conformations of the γ-tubulin ring complex (γ-TuRC) using cryo-EM and proposes a model for how conformational changes facilitate microtubule nucleation.