The paper identifies RBMP2 as essential for forming the reticulated membrane region in the algal pyrenoid, which is critical for CO2 delivery and growth.

bioRxiv · Jul 3, 2026 · PreprintPlant Biology

Quantitative Spatial Analysis of Chromatin Biomolecular Condensates using Cryo-Electron Tomography

Huabin Zhou, Joshua Hutchings, Momoko Shiozaki, Xiaowei Zhao, Lynda K. Doolittle, Shixin Yang, Rui Yan, Nikki Jean, Margot Riggi, Zhiheng Yu, Elizabeth Villa, Michael K. Rosen

The paper develops methods to analyze chromatin condensates using cryo-electron tomography and deep learning, revealing nucleosome structures and interactions in both reconstituted and native systems.

Proceedings of the National Academy of Sciences · May 6, 2025Peer-reviewedBiophysics

How short peptides can disassemble ultra-stable tau fibrils extracted from Alzheimers disease brain by a strain-relief mechanism

Ke Hou, Peng Ge, Michael R. Sawaya, Joshua L. Dolinsky, Yuan Yang, Yi Xiao Jiang, Liisa Lutter, David R. Boyer, Xinyi Cheng, Justin Pi, Jeffrey Zhang, Jiahui Lu, Shixin Yang, Zhiheng Yu, Juli F. Feigon, David S Eisenberg

The paper shows a D-peptide disassembles AD-tau fibrils via a strain-relief mechanism involving oppositely twisted fibrils.

bioRxiv · Mar 25, 2024 · PreprintNeuroscience