Erik G. Marklund

Native mass spectrometry of membrane protein lipid and ligand complexes using de novo designed WRAP domains

The paper demonstrates that WRAP domains designed with deep learning can preserve weak interactions of membrane protein complexes in native mass spectrometry, enabling characterization of lipid and ligand interactions without detergent micelles.

Membrane proteins retain native architecture through native ESI and soft-landing

This study shows that native electrospray ion beam deposition preserves membrane protein structure, enabling high-resolution cryo-EM analysis of complexes like AmtB.

Engineering cardiolipin binding to an artificial membrane protein reveals determinants for lipid-mediated stabilization

The paper investigates how cardiolipin interacts with membrane proteins to stabilize them, using a model protein and simulations to identify key factors.