Author

Hon Wing Liu

University of LausanneORCID 0000-0002-9498-6557Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:bacteria (other)· 3 Research Focus:protein structure prediction· 3 Assay:DNA methylation· 2 Research Focus:protein design· 1 Assay:protein structure· 1 Assay:structural biology· 1

Frequent Co-Authors

Stephan GruberiD· 5 shared Florian Roisné-HameliniD· 4 shared Yan LiiD· 3 shared Michael TaschneriD· 2 shared Alexander G. MyasnikoviD· 1 shared Bertrand BeckertiD· 1 shared David William AdamsiD· 1 shared Emiko UchikawaiD· 1 shared

Activity by Year

2022-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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5 shared papersMolecular Biology

Stephan GruberORCID

Mutual co-authors in cluster

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5 papers

Recent·Most cited

The SMC Hinge is a Selective Gate for Obstacle Bypass

Hon Wing Liu, Florian Roisné-Hamelin, Michael Taschner, James Collier, Madhusudhan Srinivasan, Stephan Gruber

The paper shows that SMC hinge domains selectively allow ssDNA to bypass obstacles during DNA loop extrusion, revealing a conserved mechanism across SMC complexes.

Nature Communications · Nov 25, 2025Peer-reviewedMolecular Biology

Structure and Activation Mechanism of a Lamassu Phage Defence System

Yan Li, David William Adams, Hon Wing Liu, Steven J. Shaw, Emiko Uchikawa, Milena Jaskólska, Sandrine Stutzmann, Laurie Righi, Mark D. Szczelkun, Melanie Blokesch, Stephan Gruber

The paper presents structures of a Lamassu defence system from Salmonella enterica, revealing how LmuA nuclease effector is activated by oligomerization and DNA cleavage.

Nature Structural & Molecular Biology · Oct 14, 2025Peer-reviewedMicrobiology

Structure of a Type II SMC Wadjet Complex from Neobacillus vireti

Florian Roisné-Hamelin, Hon Wing Liu, Stephan Gruber

This study determines the structure of a type II Wadjet SMC complex from Neobacillus vireti, revealing structural differences from type I systems and insights into prokaryotic SMC evolution.

Structure · Jul 7, 2025Peer-reviewedMicrobiology

Structural basis for plasmid restriction by SMC JET nuclease

Florian Roisné-Hamelin, Hon Wing Liu, Michael Taschner, Yan Li, Stephan Gruber

The paper reveals how SMC JET nuclease recognizes and cleaves plasmid DNA by mechanically bending residual unextruded DNA, identifying key structural elements involved in the process.

Molecular Cell · Feb 2, 2024Peer-reviewedMolecular Biology

DNA-measuring Wadjet SMC ATPases restrict smaller circular plasmids by DNA cleavage.

Hon Wing Liu, Florian Roisné-Hamelin, Bertrand Beckert, Yan Li, Alexander G. Myasnikov, Stephan Gruber

The paper shows JetABCD SMC complexes restrict small circular plasmids by cleaving them, while linear plasmids are not restricted, and presents a structural model for this process.

Molecular Cell · Dec 1, 2022Peer-reviewedMolecular Biology