Major depression and atherosclerotic disease: Linking shared genetics to pathways in blood, brain, heart, and atherosclerotic plaques
Emma Pruin, Meike Bartels, Ernest Diez Benavente, Noortje A. M. van den Dungen, Joost K.R. Hoekstra, Dominique P.V. de Kleijn, Lennart P. L. Landsmeer, Michal Mokrý, Gerard Pasterkamp, Brenda W.J.H. Penninx, Wouter J. Peyrot, Hester M. den Ruijter, Sander W. van der Laan, Yuri Milaneschi
This study identifies shared genetic risk between major depression and atherosclerotic diseases and links causal gene expression changes in blood, brain, and heart tissues to depression etiology.
European Neuropsychopharmacology · Jan 29, 2026Peer-reviewedGenetic & Genomic Medicine