Patrick J. Leavey

This study shows that overexpressing Meis1 and Meis2 in postnatal mouse retinal progenitor cells has distinct effects on temporal identity and neurogenesis, without fully reprogramming cell fate.

This paper introduces SLED, a splicing-based method to control gene expression in specific cell types, demonstrating its utility in targeting neurons, photoreceptors, and cancer cells.

This study shows that deleting Ptbp1 in adult retinal Muller glia and brain astrocytes does not convert glia into neurons, using genetic lineage tracing, scRNA-Seq, and electrophysiology.

This study identifies NFI factors as repressors of tanycyte-derived neurogenesis and shows their disruption promotes proliferation and neurogenesis in the hypothalamus.

ASCOT identifies key regulators of neuronal subtype-specific splicing by analyzing public RNA-Seq data and demonstrating the role of PTBP1, MSI1, and PCBP2 in rod photoreceptor splicing.