Sudeshna Roy

1,2,4-Triazole-based first-in-class non-nucleoside inhibitors of bacterial enzyme MraY

This paper discovers first-in-class 1,2,4-triazole-based non-nucleoside inhibitors of MraY with broad-spectrum antibacterial activity against multiple bacterial species.

HuR inhibition reduces post-ischemic cardiac remodeling by dampening acute inflammatory gene expression and the innate immune response

This study shows that inhibiting HuR reduces cardiac remodeling after ischemia-reperfusion injury by dampening inflammatory gene expression and immune response, but not initial infarct size.

HuR-dependent expression of Wisp1 is necessary for TGF????-induced cardiac myofibroblast activity

This study shows that HuR-dependent Wisp1 expression is necessary for TGFβ-induced cardiac myofibroblast activity, as HuR inhibition reduces ECM remodeling and contractile functions.