Frederik Sommer

The paper develops an optimized targeted metabolomics workflow for analyzing central carbon metabolism intermediates in algae and plants with high sensitivity and accuracy.

Deleting 27 CDIP-candidate genes (26 confirmed CDIPs) and two phytotoxin biosynthesis genes in Botrytis cinerea nearly abolishes apple infection but leaves slow leaf lesions, pointing to redundant, unidentified host-killing factors.

Depletion of chloroplast HSP70B causes cell division arrest, proteostasis collapse, impaired VIPP1 oligomer dynamics with aberrant thylakoid structures, and increased light sensitivity.

This study investigates the function of CDJ5 in Chlamydomonas reinhardtii by comparing its proxiomes with and without a functional 4Fe-4S cluster, revealing its role in chloroplast microcompartment localization and photosynthetic processes.

The Chlamydomonas psb28 mutant shows severe PSII assembly defects, and complexome profiling identifies TEF5 as a novel PSII assembly factor involved in CP47 assembly.

This study introduces a method to produce phycoerythrobilin in Synechocystis, demonstrating its biosynthesis and attachment to phycocyanin subunits, with minimal impact on physiological functions.

The paper identifies new substrates of the chloroplast CPN60 chaperonin machinery using competition co-immunoprecipitation and mass spectrometry in Chlamydomonas reinhardtii.

The paper integrates proteomics and constraint-based modeling to estimate in vivo enzyme turnover numbers for Chlamydomonas reinhardtii, improving metabolic model predictions.

The paper investigates the virulence of Botrytis cinerea by generating multiple knockout mutants, revealing high redundancy in phytotoxic compounds that drive necrotrophic infection.

The paper identifies early gut biomarkers for Parkinson's disease in mice and humans using a transgenic model and molecular profiling.