Shan Sun

Winnow-tax improves taxonomic profiling of low-coverage shotgun metagenomes by combining sensitive read-level classification with genome-level confirmation, achieving better precision-sensitivity balance than existing methods.

This study shows that an AGE-rich diet during adolescence impairs memory via hippocampal synaptic deficits and microbiome changes, which can be mitigated by AGE inhibitors.

This study shows Giardia reduces the beneficial effects of Lactobacillus in malnourished mice, altering microbial balance and increasing intestinal damage.

This study shows that adapting human IBD microbiota for mice improves colonization efficiency and alters microbiome aggressiveness based on the recipient's inflammatory environment.

This study shows that a western diet during development impairs memory by disrupting hippocampal acetylcholine signaling, which can be partially reversed with pharmacological intervention.

This paper evaluates classification errors in WGS datasets using Kraken2 and Metaphlan2, finding that Kraken2's errors create 'phantom' taxa that affect statistical inference.

The paper tests the biological clock hypothesis in the human gut microbiome by analyzing 11 datasets, finding that larger sample sizes are needed for consistent age-related microbial associations.

This study shows that early-life low-calorie sweetener consumption in rodents leads to long-term metabolic, behavioral, and neural impairments without weight gain.

This study shows that adolescent Western diet consumption in female rats leads to long-lasting memory and gut microbiome issues that are not fully reversed by adult dietary changes.

The paper evaluates PICRUSt's accuracy across different sample types and functional categories, finding it performs well for human samples but poorly for non-human and environmental samples.