Yanning Zuo

Acute opioid responses are modulated by dynamic interactions of Oprm1 and Fgf12

This study identifies time-dependent epistatic interactions between Oprm1 and Fgf12 that modulate opioid-induced locomotion in mice and links Fgf12 to opioid behavior in humans.

Transcription initiation profiling defines the regulatory logic of astrocyte gene regulation

This study maps transcription initiation in mouse astrocytes to define how inflammatory signals drive cell-type-specific gene regulation and links enhancer activity to human disease risk.

Single-nucleus transcriptomics reveals convergent effects of THC exposure and Reelin signaling on nucleus accumbens maturation in adolescence

This study uses single-nucleus RNA sequencing to show that adolescent THC exposure and reduced Reelin signaling both affect nucleus accumbens maturation through shared gene networks linked to substance use and psychiatric disorders.

Chronic adolescent exposure to cannabis in mice leads to sex-biased changes in gene expression networks across brain regions

This study examines sex-biased gene expression changes in mouse brain regions after adolescent THC exposure, identifying common regulatory mechanisms linked to cannabis use disorder vulnerability.

Lasting effects of low-calorie sweeteners on glucose regulation, sugar intake, and memory

This study shows that early-life low-calorie sweetener consumption in rodents leads to long-term metabolic, behavioral, and neural impairments without weight gain.