Linda Tsan

Consumption of processed foods impairs memory function through dietary advanced glycation end-products

This study shows that an AGE-rich diet during adolescence impairs memory via hippocampal synaptic deficits and microbiome changes, which can be mitigated by AGE inhibitors.

Western diet consumption impairs memory function via dysregulated hippocampus acetylcholine signaling

This study shows that a western diet during development impairs memory by disrupting hippocampal acetylcholine signaling, which can be partially reversed with pharmacological intervention.

Lasting effects of low-calorie sweeteners on glucose regulation, sugar intake, and memory

This study shows that early-life low-calorie sweetener consumption in rodents leads to long-term metabolic, behavioral, and neural impairments without weight gain.

Early life Western diet-induced memory impairments and gut microbiome changes in female rats are long-lasting despite healthy dietary intervention

This study shows that adolescent Western diet consumption in female rats leads to long-lasting memory and gut microbiome issues that are not fully reversed by adult dietary changes.

Gut microbial taxa elevated by dietary sugar disrupt memory function

This study shows that early life sugar consumption alters gut microbiota and impairs hippocampal-dependent memory in rats, with specific bacterial taxa linked to these effects.