This study shows genetic background affects the proteome in 5XFAD AD mouse models, with some disease-related modules influenced by genetic background while others are not.

10 citations

mouseproteomics

𝕏 PostBluesky

NeurosciencebioRxivPreprintFeb 1, 2023

RGS14 is neuroprotective against seizure-induced mitochondrial oxidative stress and pathology in hippocampus

Nicholas H. Harbin, Daniel J. Lustberg, Cheyenne D. Hurst…·John R. Hepler

This study shows RGS14 protects hippocampal neurons from seizure-induced mitochondrial oxidative stress and pathology by modulating excitability and signaling.

4 citations

mouseexperimental assay

𝕏 PostBluesky

NeurosciencebioRxivPreprintJun 15, 2022

Integrated Proteomics Identifies Neuritin (NRN1) as a Mediator of Cognitive Resilience to Alzheimer's Disease

Cheyenne D. Hurst, Derian A. Pugh, Measho H. Abreha…·Nicholas T. Seyfried

The paper identifies NRN1 as a mediator of cognitive resilience to Alzheimer's disease through integrative proteomic analysis and functional validation in neurons.

3 citations

humanproteomics

𝕏 PostBluesky

Systems BiologyScience AdvancesPeer-reviewedOct 21, 2020

Integrated Proteomics Reveals Brain-Based Cerebrospinal Fluid Biomarkers in Asymptomatic and Symptomatic Alzheimer’s Disease

Lenora A. Higginbotham, Lingyan Ping, Eric B. Dammer…·Nicholas T. Seyfried

The paper identifies brain-linked CSF biomarkers in Alzheimer’s disease using proteomics, revealing altered levels in both brain and CSF across different disease stages.

367 citationstop 1%

humanproteomics

𝕏 PostBluesky