Author

Siarhei Hladkou

Lund UniversityORCID 0000-0002-4354-3270Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Agata KurowskiiD· 1 shared Anahita Soltanian· 1 shared Anant MamidiiD· 1 shared Anders H. RosengreniD· 1 shared Ayaka YanagidaiD· 1 shared Fiona Louise RobertsiD· 1 shared Giuliano Giuseppe StirparoiD· 1 shared Hannah T. StuartiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperDevelopmental Biology

Agata KurowskiORCID

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2 papers

Recent·Most cited

Modelling genetic risk of β-cell dysfunction in human induced pluripotent stem cells from patients carrying the MTNR1B risk variant.

T. Singh, Sebastian Kalamajski, João Gabriel Dantas Cunha, Siarhei Hladkou, Fiona Louise Roberts, Sevda Gheibi, Anahita Soltanian, K. Yektay Farahmand, Ola Ekström, Anant Mamidi, Paul W. Franks, Anders H. Rosengren, Henrik Semb, Hindrik Mulder, Malin Fex

This study uses hiPSC and hESC to model the MTNR1B risk variant's effect on β-cell function, finding increased MTNR1B protein and melatonin sensitivity in G-allele carriers.

Journal of Pineal Research · Sep 1, 2025Peer-reviewedCell Biology

Oct4 regulates embryonic pluripotency via metabolic mechanisms and Stat3 signalling.

Giuliano Giuseppe Stirparo, Agata Kurowski, Ayaka Yanagida, Lawrence E. Bates, Stanley E. Strawbridge, Siarhei Hladkou, Hannah T. Stuart, Thorsten Boroviak, José Silva, Jennifer Nichols

This study identifies OCT4's role in maintaining pluripotency through metabolic regulation and Stat3 signaling in mouse embryos.

Proceedings of the National Academy of Sciences · Jan 15, 2021Peer-reviewedDevelopmental Biology