John F. Hancock

This study shows that galectin-3's carbohydrate recognition domain maintains plasma membrane phosphatidylserine, which is necessary for KRAS function.

This study identifies DIRAS3 as a tumor suppressor that inhibits diverse oncogenic KRAS variants through a specific inhibitory interface, with a mimetic showing broad suppression of KRAS-driven signaling.

This paper shows eIF2B activates mutant KRAS by forming a complex with SOS at the plasma membrane and regulating glycosphingolipid biosynthesis.

This study shows glycosphingolipids regulate phosphatidylserine transport at ER-PM contact sites by maintaining ORP5 and ORP8 localization and function.

The paper identifies MTMR proteins as regulators of KRAS function by controlling plasma membrane phospholipid levels, specifically PI4P and PtdSer.