Jo-Anne Chan

The paper identifies two functionally distinct Tfh1 subsets in malaria infection, showing that only CCR7pos Tfh1 and Tfh2 cells are associated with antibody development.

This study shows that latent cytomegalovirus infection reduces antibody responses to malaria infection and vaccination by altering Tfh cell subsets and their activation.

This study identifies IgM as a key antibody isotype in immune responses against Plasmodium falciparum gametocytes, showing its superior complement fixation activity compared to IgG.

This study develops a platform to display malaria transmission-blocking antigens on virus-like particles using yeast expression systems and demonstrates efficient production and purification of chimeric VLPs containing Pfs25 and Pfs230 variants.