Jiayu Fu

The paper designs and discovers a new modular transcriptional riboswitch architecture called 'tug-of-war' that suppresses intrinsic termination by ligand-stabilized RNA structures upstream of terminators.

This study shows mutant p53R172H in pancreatic cancer enhances immunosuppressive chemokine Cxcl1 expression via enhancer activation, reducing immune checkpoint inhibitor efficacy.

The paper shows that slowing RNA folding kinetics enhances riboswitch sensitivity in vivo and identifies general principles for programming RNA folding dynamics.

This study introduces scGRO-seq, a single-cell nascent RNA sequencing method using click-chemistry, revealing coordinated transcription and enhancer-gene synchrony.