Author

Emily Metcalf

Koch Institute for Integrative Cancer Research At MITORCID 0000-0003-4522-4932Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Arundeep SinghiD· 1 shared Brandon Sullivan· 1 shared Dig Bijay MahatiD· 1 shared Enrico MoisoiD· 1 shared Heena KumraiD· 1 shared Hernandez Moura SilvaiD· 1 shared Ivy X. Chen· 1 shared Jiayu FuiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Arundeep SinghORCID

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1 paper

Recent·Most cited

Cancer BiologyImmunityPeer-reviewedJul 1, 2025

Mutant p53 Exploits Enhancers to Elevate Immunosuppressive Chemokine Expression and Impair Immune Checkpoint Inhibitors in Pancreatic Cancer

Dig Bijay Mahat, Heena Kumra, Sarah A Castro…·Phillip A. Sharp

This study shows mutant p53R172H in pancreatic cancer enhances immunosuppressive chemokine Cxcl1 expression via enhancer activation, reducing immune checkpoint inhibitor efficacy.

44 citationstop 1%

humanbulk RNA-seq

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