Author

Sean K. Waterton

Koch Institute for Integrative Cancer Research At MITORCID 0000-0003-3760-5743Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Dig Bijay MahatiD· 2 shared Jiayu FuiD· 2 shared Phillip A. SharpiD· 2 shared Arundeep SinghiD· 1 shared Brandon Sullivan· 1 shared Emily MetcalfiD· 1 shared Enrico MoisoiD· 1 shared Heena KumraiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Dig Bijay MahatORCID

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2 papers

Recent·Most cited

Cancer BiologyImmunityPeer-reviewedJul 1, 2025

Mutant p53 Exploits Enhancers to Elevate Immunosuppressive Chemokine Expression and Impair Immune Checkpoint Inhibitors in Pancreatic Cancer

Dig Bijay Mahat, Heena Kumra, Sarah A Castro…·Phillip A. Sharp

This study shows mutant p53R172H in pancreatic cancer enhances immunosuppressive chemokine Cxcl1 expression via enhancer activation, reducing immune checkpoint inhibitor efficacy.

44 citationstop 1%

humanbulk RNA-seq

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GenomicsbioRxivPreprintSep 15, 2023

Single-cell nascent RNA sequencing using click-chemistry unveils coordinated transcription

Dig Bijay Mahat, Nathaniel D. Tippens, Jorge Diego Martin-Rufino…·Phillip A. Sharp

This study introduces scGRO-seq, a single-cell nascent RNA sequencing method using click-chemistry, revealing coordinated transcription and enhancer-gene synchrony.

4 citations

scRNA-seqexperimental assay

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