Author

Sarah A Castro

Koch Institute for Integrative Cancer Research At MIT

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Arundeep SinghiD· 1 shared Brandon Sullivan· 1 shared Dig Bijay MahatiD· 1 shared Emily MetcalfiD· 1 shared Enrico MoisoiD· 1 shared Heena KumraiD· 1 shared Hernandez Moura SilvaiD· 1 shared Ivy X. Chen· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Arundeep SinghORCID

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1 paper

Recent·Most cited

Mutant p53 Exploits Enhancers to Elevate Immunosuppressive Chemokine Expression and Impair Immune Checkpoint Inhibitors in Pancreatic Cancer

Dig Bijay Mahat, Heena Kumra, Sarah A Castro, Emily Metcalf, Kim Bich Nguyen, Ryo Morisue, William W. Ho, Ivy X. Chen, Brandon Sullivan, L. K. Yim, Arundeep Singh, Jiayu Fu, Sean K. Waterton, Yu‐Chi Cheng, Sylvie Roberge, , Phillip A. Sharp

This study shows mutant p53R172H in pancreatic cancer enhances immunosuppressive chemokine Cxcl1 expression via enhancer activation, reducing immune checkpoint inhibitor efficacy.

Immunity · Jul 1, 2025Peer-reviewedCancer Biology