Madeline R. Scott

Single-nucleus transcriptome-wide association study of human brain disorders

This study performs a single-nucleus transcriptome-wide association study to identify gene-trait associations in brain disorders, revealing cell-type-specific genetic regulation and ancestry-specific patterns.

Single-Nucleus Atlas of Cell-Type Specific Genetic Regulation in the Human Brain

The paper constructs a single-nucleus atlas of genetic regulation in the human brain, identifying cell-type-specific regulatory effects and disease-associated genes.

Prenatal circadian rhythm disruption induces sex-specific substance use and mood-related phenotypes in mice

This study shows that prenatal circadian rhythm disruption in mice leads to sex-specific behavioral changes in adulthood, with females showing mood-related issues and males showing substance use-like behaviors.

Unraveling Tissue-Specific Molecular Signatures and Convergent Pathway Enrichments in Suicidal Behavior

This study identifies tissue-specific molecular signatures and convergent pathways in suicide by analyzing transcriptomic data from blood and brain tissues.

Molecular and cellular rhythms in excitatory and inhibitory neurons in the mouse prefrontal cortex

This study identifies cell-type and sex-specific gene expression and electrophysiological rhythms in mouse prefrontal cortex neurons, showing differences in rhythmic transcripts and biological processes between excitatory pyramidal cells and inhibitory PV interneurons.

Comparative transcriptomic rhythms in the mouse and human prefrontal cortex

This study compares circadian transcriptomic rhythms in mouse and human prefrontal cortex subregions, finding conserved signaling with sex-specific phase shifts and species-specific rhythmic transcript identities.

A lifespan transcriptomic atlas of the human prefrontal cortex at single-cell resolution

This study creates a single-nucleus transcriptomic atlas of the human DLPFC across the lifespan, revealing three transcriptomic phases and ten age-related trajectories linked to neurodevelopmental and neurodegenerative disease risk.

The ultradian transcriptome of the human prefrontal cortex and abnormalities in schizophrenia

The paper identifies 12-hour ultradian rhythms in the human prefrontal cortex and shows disruptions in schizophrenia affecting genes related to protein processing and mitochondrial function.