Weihang Chen

The paper develops a genome-wide CRISPR-Cas9 knockout screening platform for Ixodes scapularis ticks and identifies genes associated with cellular fitness and drug resistance.

The paper maps the Drosophila secretome to identify tissue-specific origins and inter-organ trafficking of 535 blood plasma proteins.

This study uses a Drosophila model to show that CFTR loss reduces cholinergic signaling, which contributes to gut pathologies, and that restoring cholinergic signaling can rescue these phenotypes.

The paper shows that Drosophila proventriculus cells compensate for age-related cell loss through endocycling rather than stem cell proliferation.

The paper examines dendritic spine changes in mouse medial prefrontal cortex neurons during adolescence, finding greater remodeling in IT-type neurons and a role for microglia.