Chloé Mayère

An ancestral pronephric contribution reveals the multilineage origin of the teleost gonad and revises the evolution of vertebrate gonadogenesis

The paper shows that the teleost gonad originates from three embryonic tissues, challenging the idea that pronephric contribution is an amniote innovation.

Supporting-like cells constitute an alternative steroidogenic lineage conserved in amniotes

The paper identifies supporting-like cells as an alternative steroidogenic lineage in mammals, conserved across amniotes, and shows their role in embryonic development and evolution.

Ovarian development is driven by early spatiotemporal priming of the coelomic epithelium

This study shows that ovarian cellular diversity arises from spatially organized, transcriptionally heterogeneous coelomic epithelium progenitors in fetal mouse and human ovaries, which are primed toward supporting or steroidogenic identities.

Single-cell transcriptomic profiling redefines the origin and specification of early adrenogonadal progenitors

This study uses single-cell transcriptomics to redefine the origin and specification of early adrenogonadal progenitors in mice, showing distinct molecular signatures for adrenal and gonadal fates.

Loss of NR5A1 in Sertoli cells after sex determination changes their cellular identity and induces their death by anoikis

This study shows that loss of NR5A1 in Sertoli cells after sex determination leads to their transdifferentiation, anoikis, and testis abnormalities.

Origin, specification and differentiation of a rare supporting-like lineage in the developing mouse gonad

The paper identifies and characterizes a previously uncharacterized supporting-like cell lineage in developing mouse gonads, showing its origin, specification, and sex-specific differentiation.

Single cell transcriptomics reveal temporal dynamics of critical regulators of germ cell fate during mouse sex determination

The paper uses single-cell RNA sequencing to study gene expression dynamics in mouse germ cells during sex determination, identifying sex-specific regulatory patterns and meiotic gene regulation.