Iván Ruminot

APOE genotype-dependent differences in human astrocytic energy metabolism

This study investigates how different APOE genotypes affect human astrocytic energy metabolism, finding reduced ATP production in APOE4 astrocytes but increased mitochondrial respiration and glycolytic capacity.

Acute stimulation of glucose metabolism by H2O2 sustains theNADPH steady-state under oxidative stress

The paper shows that H2O2 increases NADPH production before depletion during oxidative stress by enhancing glucose metabolism.

Lactate-carried Mitochondrial Energy Overflow

The paper investigates mitochondrial lactate metabolism, finding that mitochondria produce lactate as an overflow mechanism to regulate redox levels and conserve energy.

CO2 signalling mediates neurovascular coupling in the cerebral cortex

This study shows that CO2 signalling is critical for neurovascular coupling in the somatosensory cortex, as disrupting CO2-sensitive vasodilation or HCO3-/CO2 transport abolishes the response to neuronal activity.