Author

Paul Lubrano

University of TübingenORCID 0000-0001-9282-9649Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:E. coli· 3 Approach:experimental assay· 3 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

Hannes LinkiD· 2 shared Agathe LermantiD· 1 shared Alexandra Silvain· 1 shared Alexandre Ismail· 1 shared Alicia Magnanon· 1 shared André BirgyiD· 1 shared Antoine Arvor· 1 shared Arnaud GutierreziD· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersMicrobiology

Hannes LinkORCID

Author profile →

4 papers

Recent·Most cited

Collective protection drives human gut microbiota response to amoxicillin treatment.

Paul Lubrano, Mélanie Magnan, Caroline Steiner, André Birgy, Benoît Chassaing, Mélanie Deschasaux, Arnaud Gutierrez, Hugo C. Barreto, Claire Amaris Hobson, Sophie Magréault, Vincent Jullien, Mathilde Lescat, Olivier Tenaillon

This study examines how human gut microbiotas respond to amoxicillin treatment using an in vitro model, finding that initial community composition and antibiotic inactivation dynamics influence resilience and resistance selection.

bioRxiv · Apr 24, 2026 · PreprintMicrobiology

The SPFH complex HflK-HflC regulates aerobic respiration in bacteria

María Isabel Pérez-López, Paul Lubrano, Georgia Angelidou, Sarah Hoch, Timo Glatter, Nicole Paczia, Hannes Link, Victor Sourjik

This study identifies the HflK-HflC complex as essential for aerobic respiration in E. coli by regulating IspG abundance and ubiquinone levels.

PLoS Biology · Apr 7, 2025Peer-reviewedMicrobiology

Intact protein barcoding enables one-shot identification of CRISPRi strains and their metabolic state

Vanessa Pahl, Paul Lubrano, Felicia Troßmann, Daniel Petras, Hannes Link

This paper introduces a method to simultaneously detect CRISPRi strain barcodes and metabolites using FI-MS, revealing pathway-specific metabolic changes in engineered bacteria.

Cell Reports Methods · Nov 26, 2024Peer-reviewedSynthetic Biology

A thermo-responsive plasmid for biconditional protein expression

Agathe Lermant, Alicia Magnanon, Alexandra Silvain, Paul Lubrano, Marie Lhuissier, Camille Dury, Maryne Follenfant, Zoe Guiot, Gaëtan Christien, Pauline Coudert, Antoine Arvor, Maxime Sportich, Gabrielle Vuillaume, Nicolas Delettre, Julie Henry, , Alexandre Ismail

The paper develops a thermo-responsive plasmid that selectively expresses different proteins at different temperatures but faces issues with the heat shock regulatory sequence.

bioRxiv · Mar 27, 2018 · PreprintSynthetic Biology