Author

Alexey V. Stepanov

Scripps Research InstituteORCID 0000-0003-1616-4408Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:metabolism & bioenergetics· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Yury P. RubtsoviD· 2 shared Alexander G. GabiboviD· 1 shared Alla D. FedorovaiD· 1 shared Aoife O’ConnelliD· 1 shared Audrey M. MicheliD· 1 shared Daria S. OsipovaiD· 1 shared Ding ZhangiD· 1 shared Dmitry E. AndreeviD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersImmunology

Yury P. RubtsovORCID

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2 papers

Recent·Most cited

ImmunologybioRxivPreprintJul 31, 2025

The earliest changes in the translatome upon human T cell activation

Alexey V. Stepanov, Aoife O’Connell, Phil O’Brien…·Dmitry E. Andreev

This study examines early transcriptional and translational changes in human T cells within four hours of activation, revealing dynamic gene expression and translation initiation patterns.

2 citations

humanbulk RNA-seq

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Molecular BiologyMolecular Therapy OncologyPeer-reviewedJun 27, 2024

Targeting CD45 by gene-edited CAR-T cells for leukemia eradication and hematopoietic stem cell transplantation preconditioning

Valeria M. Stepanova, Dmitry V. Volkov, Daria S. Osipova…·Alexey V. Stepanov

This paper demonstrates the preclinical efficacy of CD45-targeting CAR T and NK cells for leukemia treatment and HSCT preconditioning, showing reduced fratricide through gene editing.

9 citations

humanexperimental assay

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