Author

Raoul J. de Groot

Utrecht UniversityORCID 0000-0002-2207-9472Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Frank J. M. van KuppeveldiD· 2 shared Adam S. FrostiD· 1 shared Advait SubramanianiD· 1 shared Aniliese DealiD· 1 shared Berend‐Jan BoschiD· 1 shared Christopher P. ArthuriD· 1 shared Cornelis A. M. de HaaniD· 1 shared D. John LeeiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

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2 shared papersMicrobiology

Frank J. M. van KuppeveldORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Spike and host glycan determinants of HKU1 airway tropism

Robert Creutznacher, Louisa E. Wallace, Oliver J. Debski-Antoniak, Ieva Drulyte, Ruben J. G. Hulswit, Jeffrey Matthijn Beekman, Frank J. M. van Kuppeveld, Berend‐Jan Bosch, Cornelis A. M. de Haan, Martin Frank, Daniel L. Hurdiss, Raoul J. de Groot

This study identifies spike and host glycan determinants of HKU1 airway tropism by showing preferential binding to 9-O-acetylated 2,8-linked disialosides and structural insights into ligand recognition.

bioRxiv · Aug 5, 2026 · PreprintMicrobiology

Allosteric Disordering of eIF2B Regulates the Integrated Stress Response

Udit Dalwadi, Advait Subramanian, Aniliese Deal, Julia E. Conrad, Tamara Nadjsombati, Meera Venkatesh, Morgane Boone, Pascal F. Egea, Ling-jie He, Nimit Jain, D. John Lee, Yuwei Liu, Lucas Charles Reineke, Kazuki Saito, Nathaniel Talledge, , Adam S. Frost

This study identifies an allosteric mechanism in eIF2B that regulates the Integrated Stress Response by showing how eIF2-P binding inhibits eIF2B activity through latch-helix dislocation.

Nature Chemical Biology · Jun 29, 2026Peer-reviewedBiochemistry