Sven Truckenbrodt

Structural basis for GluA1 AMPA receptor regulation by PRRT1/SynDIG4 in LTP

This study identifies PRRT1/SynDIG4's role in regulating GluA1 AMPA receptors during LTP by sequestering the GluA1 C-terminus via a lipid modification, thereby affecting CaMKII access and LTP induction.

Combinatorial protein barcodes enable self-correcting neuron tracing with nanoscale molecular context

The paper introduces PRISM, a platform that uses combinatorial protein barcodes to enable self-correcting neuron tracing with molecular context, improving tracing accuracy and handling spatial gaps.

Super-resolution expansion microscopy in plant roots

This study develops and applies expansion microscopy to Arabidopsis root tissues, achieving improved resolution and visualizing subcellular structures.

Ageing synaptic vesicles are inactivated by contamination with SNAP25

The paper shows that aged synaptic vesicles are inactivated by SNAP25 contamination, which inhibits exocytosis and promotes co-localization with recycling endosomes.