The paper shows that mitotic chromosome condensation resets transcriptional homeostasis by preventing unscheduled gene expression and transcriptional drift in the subsequent interphase.

Proceedings of the National Academy of Sciences · Jan 19, 2023Peer-reviewedMolecular Biology

Waves of sumoylation support transcription dynamics during adipocyte differentiation

Xu Zhao, Ivo Alexander Hendriks, Stéphanie Le Gras, Tao Ye, Lucía Ramos-Alonso, Aurélie Nguéa P, Guro Flor Lien, Fatemeh Ghasemi, Arne Klungland, Bernard Jost, Jorrit M. Enserink, Michael Lund Nielsen, Pierre Chymkowitch

This study identifies the dual role of sumoylation in adipocyte differentiation by regulating gene expression and transcriptional network rewiring through SLAMseq and ChIPseq.

Nucleic Acids Research · Jan 10, 2022Peer-reviewedGenomics

Extensive NEUROG3 occupancy in the human pancreatic endocrine gene regulatory network

Valérie Schreiber, Reuben Mercier, Sara Jiménez, Tao Ye, Emmanuel García Sánchez, Annabelle Klein, A. Meunier, Sabitri Ghimire, Catherine Birck, Bernard Jost, Kristian Honnens de Lichtenberg, Christian Honoré, Palle Serup, Gérard Gradwohl

This study maps NEUROG3 occupancy in human pancreatic endocrine progenitors, identifying 1268 target genes and linking NEUROG3 to islet cell development and type 2 diabetes risk variants.

Molecular Metabolism · Aug 2, 2021Peer-reviewedGenomics