Author

Paula Ortega-Prieto

MRC London Institute of Medical SciencesORCID 0000-0003-1267-024XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Assay:imaging· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Alexis R. BarriD· 2 shared Louise FetsiD· 2 shared Alex MontoyaiD· 1 shared Betheney R. PennycookiD· 1 shared Bhavik PateliD· 1 shared Boris LenhardiD· 1 shared Carmen Ramírez-MoncayoiD· 1 shared Chad Whilding· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Alexis R. BarrORCID

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2 papers

Recent·Most cited

Multimodal imaging reveals a lysosomal drug reservoir that drives heterogeneous distribution of PARP inhibitors

Carmen Ramírez-Moncayo, Restuadi Restuadi, Guanying Zhang, Daniel Marks, Paula Ortega-Prieto, Emily Doherty, Nathalie Lambie, Chad Whilding, Ivan Andrew, Alex Montoya, Bhavik Patel, Katie Tyson, Betheney R. Pennycook, Lauren Pendergast, Vincen Wu, , Louise Fets

The paper uses multimodal imaging to show that lysosomes act as a reservoir for PARP inhibitors, leading to heterogeneous drug distribution and response in ovarian cancer.

Nature Communications · Mar 17, 2026Peer-reviewedCancer Biology

Pro-survival roles for p21(Cip1/Waf1) in Non-Small Cell Lung Cancer

S. J. Cutty, Fern A Hughes, Paula Ortega-Prieto, S. Desai, Philipp Thomas, Louise Fets, Maria Secrier, Alexis R. Barr

This study shows that p21Cip1/Waf1 promotes survival and relapse in TP53 wild-type NSCLC by enabling quiescence and protecting cells from chemotherapy.

British Journal of Cancer · Dec 20, 2024Peer-reviewedCancer Biology