Makiko Iwafuchi

The paper shows that PRDM1 collaborates with pioneer TFs to enhance enhancer repression during human endoderm differentiation, preserving lineage fidelity through hyper-bivalent enhancers.

This study investigates the role of ZMYND11 in neurodevelopment by analyzing its effects on cortical neural stem cells and splicing regulation in ASD risk factors.

The paper shows that MAPK/ERK signaling prevents H3K9me3 heterochromatin formation at lineage-specific gene loci during mesoderm and endoderm differentiation from human pluripotent stem cells.

The paper identifies and characterizes a new population of early hepatoblasts in mouse and human liver development, showing their role in liver bud formation and their decline in later stages.