Carl D. Modes

This study quantifies lipid sorting during clathrin-mediated endocytosis and finds that lipid asymmetry in the plasma membrane explains observed partitioning, with minimal selectivity for cytoplasmic leaflet lipids compared to non-vesicular trafficking.

The paper shows that integrin-mediated adhesion sites coordinate tissue flows during Drosophila gastrulation by balancing cell-intrinsic forces with spatially distributed anchoring.

SpinePy provides a framework for 3D spatiotemporal quantification of multicellular systems by aligning data to dynamic internal coordinate systems, revealing patterning classes influenced by gastruloid volume.

The paper investigates how apical forces drive optic cup invagination during vertebrate eye development through coordinated cell behaviors and physical modeling.

This study shows that anisotropic stretch biases actin fiber orientation in Hydra cell aggregates during self-organization from a disordered state.

The paper shows that nuclear shape changes and packing order during neurogenesis are critical for retinal lamination in zebrafish.

The paper investigates the role of core PCP mutations in Drosophila pupal wing morphogenesis and finds they do not affect tissue shape changes but influence fast mechanical responses.

The paper shows that the cephalic furrow in fly embryos evolved to prevent mechanical instabilities during gastrulation by absorbing compressive stresses.

The paper shows that extracellular matrix topology influences collective cell migration during zebrafish optic cup formation by affecting cryptopodia formation and migration efficiency.

The paper investigates how extracellular matrix properties influence nuclear shape, organization, and cell fate in embryonic midline sutures through physical and genetic analyses.

The paper investigates the effects of communication in a network of cells on dynamic concentration-sensing, showing that super-Poissonian dynamics reduce MSE with more neighbors, while Poissonian dynamics only speed up convergence.

The paper presents a multi-sample imaging, processing, and analysis platform for studying vascular growth in zebrafish over time.