Yoshiaki Nishimura

This study shows that co-delivering PD-L1 with an AAV-expressed HIV-1 bNAb reduces anti-drug antibodies and improves bNAb expression and protection against HIV in rhesus macaques.

This study shows that co-delivering PD-L1 with AAV-delivered bNAb 10-1074 reduces ADA responses and improves bNAb durability in rhesus macaques.

This study examines memory and germinal center B cell responses in rhesus macaques after booster immunization, finding that high affinity memory B cells form a reservoir that participates in immune development regardless of boosting site.

This paper designs and tests an HIV-1 vaccine candidate that targets three bNAb epitopes, showing it elicits combined immune responses in animal models.