Gabriela S. Silva Santos

Antibody Mediated Diversification of Primary and Secondary Humoral Immune Responses

This study shows that secreted antibodies significantly diversify primary and secondary humoral immune responses in mice, even at low antibody levels, with implications for vaccine design.

Fc receptor dependent and independent mechanisms of antibody-mediatedenhancement of immune responses

This study identifies Fc gamma receptor-dependent and independent mechanisms by which pre-existing antibodies enhance germinal center and plasmablast responses and alter the affinity threshold for B cell recruitment.

Memory B cell Development in Response to mRNA SARS-CoV-2 and Nanoparticle Immunization in Mice

This study compares memory B cell responses to mRNA and nanoparticle vaccines in mice, finding similar antibody sequences but better breadth from mosaic nanoparticle vaccines.

HIV-1 expression is heterogeneous among clones of CD4+ T cells carrying authentic intact latent proviruses

The paper examines HIV-1 expression in CD4+ T cell clones with latent proviruses, finding heterogeneous expression and limited response to latency reversing agents.

Clonal Expansion and Diversification of Germinal Center and Memory B Cell Responses to Booster Immunization in Primates

This study examines memory and germinal center B cell responses in rhesus macaques after booster immunization, finding that high affinity memory B cells form a reservoir that participates in immune development regardless of boosting site.

Affinity maturation of antibody responses is mediated by differential plasma cell proliferation

The paper shows that high-affinity B cells divide more and receive more Tfh help, leading to affinity maturation in plasma cells.

Transcription of HIV-1 at sites of intact latent provirus integration

This study examines transcription of HIV-1 at sites of intact latent provirus integration in T cells, finding that latent proviral promoters are significantly less active than in productively infected cells and have minimal impact on neighboring gene expression.