Author

Frank Zimmermann

Heidelberg University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Marc FreicheliD· 2 shared Alex CorneaniD· 1 shared Beate Hilbert· 1 shared Eleonora AronicaiD· 1 shared Eva Haas· 1 shared James Dominic MillsiD· 1 shared Jeannette Hübener‐SchmidiD· 1 shared Joachim WittbrodtiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersGenetics

Marc FreichelORCID

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3 papers

Recent·Most cited

Precise generation of bystander-free mouse models with ABE9-SpRY.

Jun Kai Ong, Sayari Bhunia, Beate Hilbert, Vanessa Kirschner, Sascha Duglosz, Frank Zimmermann, Marc Freichel, Alex Cornean

This paper introduces ABE9-SpRY, an improved adenine base editor that generates precise point mutations in mouse embryos with high efficiency and reduced off-target effects.

Scientific Reports · Feb 20, 2026Peer-reviewedGenetics

Efficient single copy integration via homology-directed repair (scHDR) by 5'modification of large DNA donor fragments in mice

Rebekka Medert, Thomas Thumberger, Tinatini Tavhelidse, Tobias Hub, Tanja Kellner, Yoko Oguchi, Sascha Dlugosz, Frank Zimmermann, Joachim Wittbrodt, Marc Freichel

This study demonstrates that 5-biotinylation of donor DNA enhances single-copy HDR in mice, achieving 19-26% efficiency in generating conditional alleles.

Nucleic Acids Research · Dec 12, 2022Peer-reviewedMolecular Biology

A novel Ataxin-3 knock-in mouse model mimics the human SCA3 disease phenotype including neuropathological, behavioral, and transcriptional abnormalities

Eva Haas, Rana Dilara Incebacak Eltemur, Thomas Hentrich, Yacine Maringer, Thorsten Schmidt, Frank Zimmermann, Nicolas Casadei, James Dominic Mills, Eleonora Aronica, Olaf Rieß, Julia Maria Schulze-Hentrich, Jeannette Hübener‐Schmid

This paper describes a novel Ataxin-3 knock-in mouse model that replicates key neuropathological, behavioral, and transcriptional features of human SCA3 disease.

bioRxiv · Feb 28, 2020 · PreprintNeuroscience