Author

Ding Zhang

Scripps Research InstituteORCID 0000-0002-3501-5486Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Microbiology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:host-pathogen & immune response· 1 Research Focus:perturbation response prediction· 1 Assay:proteomics· 1 Assay:structural biology· 1

Frequent Co-Authors

Ian A. WilsoniD· 2 shared Peng WuiD· 2 shared Xueyong ZhuiD· 2 shared Alba Gabarroca GarcíaiD· 1 shared Alexander G. GabiboviD· 1 shared Alexey V. StepanoviD· 1 shared Alvin X. HaniD· 1 shared Cindy M. SpruitiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersCancer Biology

Ian A. WilsonORCID

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3 papers

Recent·Most cited

Affinity Maturation Enables Dual Targeting of Cancer-Associated MUC1-Tn/STn and Drives Potent Tumor Control

Jinfeng Ye, Xueyong Zhu, Huinan Lu, Jessica D. Coppola, Ding Zhang, Yinping Tian, Zhuo Yang, Shereen Chung, Leigh-Anne Cui, Jinghao Zhi, Liuqing Wen, Jianzhong Xi, Ian A. Wilson, Joseph Jardine, Peng Wu

This study affinity-matures an antibody to recognize both MUC1-Tn and MUC1-STn glycoforms, enhancing its efficacy against heterogeneous tumors.

bioRxiv · Oct 26, 2026 · PreprintCancer Biology

The receptor binding properties of H5Nx influenza A viruses have evolved to promiscuously bind to avian-type mucin-like O-glycans

Julia Weber, Niels L.D. Ponse, Xueyong Zhu, María Ríos Carrasco, Alvin X. Han, Mathis Funk, Ting-Hui Lin, Alba Gabarroca García, Cindy M. Spruit, Ding Zhang, Wenli Yu, Ian A. Wilson, Mathilde Richard, Geert‐Jan Boons, Robert P. de Vries

This study identifies that H5Nx influenza A viruses bind promiscuously to avian-type mucin-like O-glycans, enhancing their zoonotic potential by binding human tracheal tissues.

PLoS Pathogens · Jan 20, 2026Peer-reviewedMicrobiology

Targeting CD45 by gene-edited CAR-T cells for leukemia eradication and hematopoietic stem cell transplantation preconditioning

Valeria M. Stepanova, Dmitry V. Volkov, Daria S. Osipova, Wenjian Wang, Yingqin Hou, Dmitry Pershin, Maria Fadeeva, Ekaterina A. Malakhova, Elena A. Kulakovskaya, LYU Cuicui, Zhao Mingfeng, Hongkai Zhang, Jia Xie, Ding Zhang, Ilgar Z. Mamedov, , Alexey V. Stepanov

This paper demonstrates the preclinical efficacy of CD45-targeting CAR T and NK cells for leukemia treatment and HSCT preconditioning, showing reduced fratricide through gene editing.

Molecular Therapy Oncology · Jun 27, 2024Peer-reviewedMolecular Biology