Srinivasa R. Rao

This paper introduces ARMS DNAseq, a scalable spatial genomic assay that maps copy number subclones in archival tissue, revealing tumor evolution and subclone associations with morphology and transcriptomic features.

This paper introduces a 3D microdissection method combining CNC milling and light-sheet microscopy to study tumor evolution in complex 3D structures.

This study evaluates the impact of a 3D pathology workflow on DNA, RNA, and protein integrity, showing minimal effect on amplifiability and transcriptomic profiles.

This study shows bisphosphonates reduce senescence markers and alter proteomes in multiple cell types, suggesting anti-ageing effects beyond bone health.

This study shows high cholesterol increases myeloma tumour burden and promotes resistance to bortezomib by elevating resistin levels in bone marrow.

The paper evaluates the accuracy of transcript-based inferred tumor phylogenies compared to DNA-based phylogenies in prostate cancer using single-cell, spatial transcriptomic, and bulk data.