This study uses snRNA-seq to analyze cortical cell types in HD mice, revealing differential vulnerability and identifying ER-phagy as a protective pathway in HD.

bioRxiv · Nov 28, 2025 · PreprintNeuroscience

Alpha-Synuclein aggregates inhibit ESCRT-III through sequestration and collateral degradation

Cole S. Sitron, Victoria A. Trinkaus, Ana Galesic, Maximilian Garhammer, Patricia Yuste‐Checa, Ulrich Dransfeld, Dennis Feigenbutz, Jiuchun Zhang, Larysa Ivashko, Irina Dudanova, J. Wade Harper, F. Ulrich Hartl

This study shows that alpha-synuclein fibrils sequester and degrade ESCRT-III proteins, leading to endolysosomal damage and increased alpha-synuclein aggregation.

Molecular Cell · Sep 1, 2025Peer-reviewedBiochemistry

Neuroprotective effects of hepatoma-derived growth factor in models of Huntington's disease

Kerstin Voelkl, Sara Gutiérrez-Ángel, Sophie Keeling, Seda Koyuncu, Miguel da Silva Padilha, Dennis Feigenbutz, Thomas Arzberger, David Vı́lchez, Rüdiger Klein, Irina Dudanova

This study shows that hepatoma-derived growth factor (HDGF) has neuroprotective effects in Huntington's disease models by reducing mutant Huntingtin toxicity and aggregation.

Life Science Alliance · Aug 14, 2023Peer-reviewedNeuroscience