Irina Dudanova

Anle138b reduces mHTT aggregates and improves disease phenotypes in HD cell and mouse models.

This study uses snRNA-seq to analyze cortical cell types in HD mice, revealing differential vulnerability and identifying ER-phagy as a protective pathway in HD.

This study shows that alpha-synuclein fibrils sequester and degrade ESCRT-III proteins, leading to endolysosomal damage and increased alpha-synuclein aggregation.

The paper shows optogenetic activation of VIP-INs in HD mice restores motor function by normalizing activity in VIP-INs and CSPNs.

This study shows that hepatoma-derived growth factor (HDGF) has neuroprotective effects in Huntington's disease models by reducing mutant Huntingtin toxicity and aggregation.

The paper develops a mouse model with a proteostasis reporter to study how cytoplasmic and nuclear protein aggregates affect neuronal protein quality control in aging and disease.

This study shows that cortical circuit alterations, including increased neuronal activity and reduced inhibitory synapses, occur before disease onset in Huntington’s disease mice.