Author

Maximilian Garhammer

Max Planck Institute of BiochemistryORCID 0000-0002-9755-4733Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:host-pathogen & immune response· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

F. Ulrich HartliD· 2 shared Ana GalesiciD· 1 shared Benjamin F. CravattiD· 1 shared Bruno N. MelilloiD· 1 shared Cole S. SitroniD· 1 shared Dennis FeigenbutziD· 1 shared Evert NjomeniD· 1 shared Haoxin LiiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

F. Ulrich HartlORCID

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2 papers

Recent·Most cited

Tryptoline Stereoprobe Elaboration Identifies Inhibitors of the GRPEL1-HSPA9 Chaperone Complex

Rachel E. Hayward, Raymond F. Berkeley, Zijian Gao, Maximilian Garhammer, Marc A. Morizono, Evert Njomen, Haoxin Li, Kristen E. DeMeester, Victor Cociorva, Mark A. Herzik, F. Ulrich Hartl, Bruno N. Melillo, Benjamin F. Cravatt

The paper identifies inhibitors of the GRPEL1-HSPA9 chaperone complex using tryptoline stereoprobes and shows they target non-orthosteric sites.

bioRxiv · Oct 20, 2025 · PreprintBiochemistry

Alpha-Synuclein aggregates inhibit ESCRT-III through sequestration and collateral degradation

Cole S. Sitron, Victoria A. Trinkaus, Ana Galesic, Maximilian Garhammer, Patricia Yuste‐Checa, Ulrich Dransfeld, Dennis Feigenbutz, Jiuchun Zhang, Larysa Ivashko, Irina Dudanova, J. Wade Harper, F. Ulrich Hartl

This study shows that alpha-synuclein fibrils sequester and degrade ESCRT-III proteins, leading to endolysosomal damage and increased alpha-synuclein aggregation.

Molecular Cell · Sep 1, 2025Peer-reviewedBiochemistry