Ido Caspy

Molecular architecture of colossal surface layers from hyperthermophilic archaea

This study determines the structure of a large S-layer protein from Pyrobaculum arsenaticum using cryo-EM and AlphaFold, revealing its unique multidomain architecture and evolutionary conservation.

Tissue-Like Multicellular Development Triggered by Mechanical Compression in Archaea

This study shows mechanical compression induces tissue-like multicellularity in haloarchaea, forming structures with distinct molecular and mechanical features similar to eukaryotic tissues.

The mechanics of a continuous self-assembling surface-layer aids cell division in an archaeon

The paper shows that the S-layer in Sulfolobus acidocaldarius aids cell division by reshaping the cytokinetic furrow through its flexible self-assembly, enhancing ESCRT-III-dependent division under mechanical stress.