Thierry Lorca

The extraordinary robustness of mitotic spindle assembly to microtubule dynamics plasticity revealed by end-binding proteins and tubulin tagging

The paper compares microtubule dynamics in C. elegans embryos using fluorescent labels and finds high variability, with spindle assembly robustness despite dynamic changes and potential issues with tagged end-binding proteins.

FAM122A inhibition of PP2A-B55 through a bipartite binding mechanism

This study identifies a bipartite binding mechanism of FAM122A to PP2A-B55, revealing a conserved phosphorylation site involved in cell cycle regulation.

Greatwall depletion from Xenopus oocytes reveals a key role of the cyclin B/CDK1-PP2A-B55 balance in the coordination of meiotic events

This study shows that Greatwall kinase coordinates meiotic divisions by regulating PP2A-B55, which controls APC/C and Mos/MAPK pathways in Xenopus oocytes.

Molecular basis for the activation of Aurora A and Plk1 kinases during mitotic entry

This paper identifies how Bora activates Aurora A and Plk1 kinases during mitosis through structural and biochemical analysis.

The study of the determinants controlling Arpp19 phosphatase-inhibitory activity reveals a new Arpp19/PP2A-B55 feedback loop

This study identifies molecular determinants controlling Arpp19 phosphatase-inhibitory activity and reveals a feedback loop between two phosphorylation sites.