Author

Jacob D. Bradbury

University of OxfordORCID 0000-0003-2016-833XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 2 Organism:E. coli· 1 Research Focus:protein folding & dynamics· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

Thomas Lanyon‐HoggiD· 3 shared Adam ThomasiD· 1 shared Amber Y. Sefton· 1 shared Andrew M. EdwardsiD· 1 shared Brigitte LamyiD· 1 shared Edward W. TateiD· 1 shared Elita JauneikaiteiD· 1 shared Emilia K. TayloriD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersMicrobiology

Thomas Lanyon‐HoggORCID

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3 papers

Recent·Most cited

A novel ciprofloxacin analogue enables daptomycin-mediated killing of resistant Staphylococcus aureus by increasing septum formation

Amber Y. Sefton, Elita Jauneikaite, Kam Pou Ha, Ravi Singh, Jacob D. Bradbury, Brigitte Lamy, Frederic J. Laurent, Edward W. Tate, Thomas Lanyon‐Hogg, Andrew M. Edwards

The paper shows that IMP-1700, a ciprofloxacin analogue, increases septum formation in S. aureus, enhancing daptomycin's effectiveness against resistant strains.

bioRxiv · Aug 24, 2026 · PreprintMicrobiology

Chemical proteomics identifies signal peptidase IB (SpsB) as a target of the SOS response inhibitor OXF-077 and a regulator of quinolone resistance emergence in Staphylococcus aureus

Jacob D. Bradbury, Timothy Rutland Walsh, Thomas Lanyon‐Hogg

Cell chemical biology · May 20, 2026Peer-reviewedMicrobiology

Live-Cell Chemoproteomic Profiling Identifies the Uncharacterised Protein YbaA as a Direct Target of Ciprofloxacin in Escherichia coli

Tricia C.Y. Seow, Jacob D. Bradbury, Emilia K. Taylor, Ludwig G. Bauer, Madia Harvey, Hildur Hreidarsdottir, Soraya M. Saghbini, Yiqiao Wang, Adam Thomas, Patrícia Santos Barbosa, K. Huber, Georgia L. Isom, Thomas Lanyon‐Hogg

This study identifies YbaA as a new ciprofloxacin-binding protein in E. coli using AfBPP and validates its interaction through genetic and biophysical assays.

bioRxiv · Oct 16, 2025 · PreprintMicrobiology