Benjamin Freedman

This study shows that high glucose in kidney organoids causes inflammation and epithelial detachment, which can be reversed by targeting cytokines and signaling pathways.

This study shows that optimizing the microenvironment with specific factors improves kidney organoid longevity and enables the formation of joint basement membranes between epithelial and endothelial cells.

The paper designs and characterizes trivalent miniprotein binders that neutralize SARS-CoV-2 variants with low pM IC50 values and provide prophylactic and therapeutic protection in mice.

The paper uses genome-edited human kidney organoids and single-cell transcriptomics to study APOL1 risk variants' effects on kidney disease mechanisms.

The paper identifies a transcriptional signature of glomerular disease using single-cell profiling of human kidney organoids and validates it in disease cohorts.