Mary C. Regier

This study shows that high glucose in kidney organoids causes inflammation and epithelial detachment, which can be reversed by targeting cytokines and signaling pathways.

This study shows that optimizing the microenvironment with specific factors improves kidney organoid longevity and enables the formation of joint basement membranes between epithelial and endothelial cells.

This paper introduces a hydrogel platform with reversible stiffness tuning and cell recovery capabilities to study mechanobiological effects on cell behavior and transcriptome responses.

The paper establishes a single-cell atlas of human tooth development and uses it to guide the in vitro differentiation of ameloblasts from iPSCs, developing a mineralizing enamel organoid system.