Didier Decaudin

This study compares two humanized mouse models for cancer immunotherapies, finding differences in immune cell engraftment and tumor response to T-cell-directed therapies.

This paper shows that the SF3B1 inhibitor pladienolide B inhibits DNA damage repair and counteracts platinum resistance in NSCLC by inducing genomic instability and altering DNA repair gene splicing.

The paper uses multi-omics analysis to compare malignant and normal uveal melanocytes, identifying genomic instability and a BAP1 promoter deletion as key features of uveal melanoma.