Yad Ghavi-Helm

This study identifies how epithelial morphogens guide stepwise mesodermal specification to generate muscle diversity in Drosophila leg development.

The paper shows core promoters restrict enhancer inputs to achieve spatiotemporal specificity in gene expression using the Drosophila twist E3 enhancer as a model.

Spatial-scERA reconstructs spatial single-cell enhancer activity in multicellular organisms using integrated transcriptomic and spatial data.

The paper identifies Collagen XV-B and Tenascin C as ECM components guiding motor axon growth through their dual topology and stiffness in zebrafish.

The paper shows enhancer-promoter interactions can occur across TAD boundaries and large genomic distances, challenging the idea that TADs strictly constrain such interactions.

This study shows that m6A RNA methylation regulates RNAP II promoter-proximal pausing, affecting gene expression and transcription.

The paper investigates how the Drosophila dosage compensation complex activates X chromosome genes through chromosome looping within the active compartment.

FourCSeq identifies specific genomic interactions in 4C sequencing data and detects changes across conditions using statistical methods.