Katie S. Kindt

Spontaneous calcium transients in hair cell stereocilia

This study detects spontaneous calcium transients in hair cell stereocilia using fluorescent sensors and microscopy, showing they originate from mechanoelectrical transduction channels and occur in multiple stereocilia regions.

Microtubule networks in zebrafish hair cells facilitate presynapse transport and fusion during development

This study shows that microtubule networks in zebrafish hair cells transport and fuse ribbon precursors to form presynaptic densities during development.

Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels

The paper shows that CIB2/3 and TMC1/2 form complexes essential for hair-cell mechanotransduction in vertebrates, supported by structural and functional analyses.

Kif1a and intact microtubules maintain synaptic-vesicle populations at ribbon synapses in zebrafish hair cells

The paper shows that Kif1a and microtubules are essential for maintaining synaptic-vesicle populations at ribbon synapses in zebrafish hair cells, affecting neurotransmission and behavior.

Contributions of mirror-image hair cell orientation to mouse otolith organ and zebrafish neuromast function

This study investigates the role of GPR156 in mouse and zebrafish sensory organs, showing it relays orientation and transduction information but not afferent selectivity for direction-specific stimuli.

Presynaptic Nrxn3 is essential for ribbon-synapse assembly in hair cells

This study identifies Nrxn3 as essential for ribbon-synapse assembly in hair cells across mouse and zebrafish models, showing its critical role in synaptic function without affecting acoustic startle behavior.

Identification of transcription factors involved in the specification of photoreceptor subtypes

The paper identifies transcription factors critical for photoreceptor subtype specification using transcriptomic profiling and CRISPR screening in zebrafish.

Prolonged dexamethasone exposure enhances zebrafish lateral-line regeneration but disrupts mitochondrial homeostasis and hair cell function

This study shows that prolonged dexamethasone exposure promotes lateral-line hair cell regeneration in zebrafish but impairs mitochondrial function and hair cell resilience to ototoxic stress.

Chronic neurotransmission increases the susceptibility of lateral-line hair cells to ototoxic insults

The paper shows that blocking neurotransmission in zebrafish hair cells reduces their susceptibility to ototoxic insults like neomycin by decreasing mitochondrial activity and ROS buildup.

Using light-sheet microscopy to study spontaneous activity in the developing lateral-line system

This study uses light-sheet microscopy to investigate spontaneous activity in the developing zebrafish lateral-line system, showing that hair cells and surrounding cells autonomously generate spontaneous calcium activity.

Synaptic mitochondria are critical for hair-cell synapse formation and function

The paper shows that mitochondrial calcium uptake in zebrafish hair cells is essential for synapse formation and function, linking presynaptic calcium influx to ribbon formation through redox regulation.

Retrograde mitochondrial transport is essential for mitochondrial homeostasis in neurons

This study shows retrograde mitochondrial transport is essential for maintaining mitochondrial homeostasis and synaptic activity in neurons.