Pilar Domingo‐Calap

Isolation and characterization of broad-range Staphylococcus epidermidis sepunaviruses

This study isolates and characterizes four broad-range Staphylococcus epidermidis phages, identifies host resistance mechanisms, and highlights their potential for phage therapy.

Phenotypic Heterogeneity Shapes Phage Resistance and Cocktail Efficacy in Klebsiella pneumoniae

This study shows that phenotypic heterogeneity in Klebsiella pneumoniae affects phage resistance and cocktail efficacy, with acapsular variants being more susceptible to phages and sustaining cocktail effectiveness under selective pressure.

Lipid metabolic pathways determine phage infectivity in Mycobacterium abscessus

This study identifies lipid metabolic pathways as key determinants of phage infectivity in Mycobacterium abscessus by analyzing phage-resistant mutants and their genetic and transcriptional changes.

Phage-meropenem synergy against OXA-48-producing Klebsiella pneumoniae clinical isolates

This study evaluates the synergy between phage vB_Kpn_2-P4 and meropenem against OXA-48-producing K. pneumoniae isolates, showing prevention of resistant mutant emergence.

Quasineutral dynamics shape coexistence and clearance in a model ofin vitro phage-bacteria interactions

The paper analyzes a mathematical model of phage-bacteria interactions to show coexistence and clearance dynamics governed by quasineutral equilibria and bifurcations.

Coevolution of a phage cocktail constrains reversible phenotypic resistance in K. pneumoniae

This study shows that coevolution with a phage cocktail reduces reversible phenotypic resistance in K. pneumoniae by forcing mutation-based resistance.

Unlocking data in Klebsiella lysogens to predict capsular type-specificity of phage depolymerases

This paper models phage depolymerase capsular tropism using graph neural networks and sequence clustering, showing predictive ability and transferability to lytic phages.

Phenotypic resistance to phage infection through capsule expression shutdown in Klebsiella pneumoniae

The paper shows that Klebsiella pneumoniae can resist phage infection through reversible downregulation of capsule biosynthesis without genetic mutations.

Mobile Integrons Encode Phage Defense Systems

The paper identifies novel phage resistance systems encoded in mobile integrons and shows they can be combined for multi-phage and antibiotic resistance with variable fitness costs.

Evolutionary strategies of Klebsiella phages in a host-diverse environment

This study evolves a 12-phage cocktail in a diverse Klebsiella environment, revealing strategies for host range modulation through receptor binding proteins and ecological dynamics.

DepoScope: accurate phage depolymerase annotation and domain delineation using large language models

DepoScope uses large language models to accurately annotate phage depolymerases and their domains, improving detection through sequence and amino-acid level predictions.