Author

Daniele Arosio

National Research CouncilORCID 0000-0003-2872-6906Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

Alberto Egidi· 1 shared Alessandro UmbachiD· 1 shared Andrew D. BealeiD· 1 shared Anna CeresetoiD· 1 shared Anna FassioiD· 1 shared Carmelo GentileiD· 1 shared Caterina Balsi· 1 shared Claudia LodovichiiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperNeuroscience

Alberto Egidi

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2 papers

Recent·Most cited

iClima: a ratiometric genetically encoded sensor for optical imaging of fast GABAergic chloride currents in vitro and in vivo

Giacomo Pasquini, Simone Giubbolini, Gabriele Nardi, Marco Brondi, Erko Beyene, Caterina Balsi, Alberto Egidi, Hanako Tsushima Semini, Silvia Landi, Marta Stancampiano, Andrew D. Beale, Emily M. Watson, Rachel S. Edgar, John Stuart O'Neill, Daniele Arosio, , Gian Michele Ratto

The paper introduces iClima, a ratiometric genetically encoded sensor for imaging GABAergic chloride currents, showing it can detect Cl- transients in vitro and in vivo with improved photostability and pH independence.

bioRxiv · Sep 2, 2026 · PreprintNeuroscience

Functional rescue of F508del-CFTR through revertant mutations introduced by CRISPR base editing

Irene Carrozzo, Giulia Maule, Carmelo Gentile, Alessandro Umbach, Matteo Ciciani, Daniela Guidone, Martina De Santis, Gianluca Petris, Luis J. V. Galietta, Daniele Arosio, Anna Cereseto

This study uses CRISPR base editing to introduce revertant mutations in F508del-CFTR, rescuing protein folding and function in CF patient-derived cells.

Molecular Therapy · Jan 9, 2025Peer-reviewedBioengineering