Author

ZZ Zhao Zhang

Duke UniversityORCID 0000-0002-3358-8459Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

ZZ Zhao Zhang2 papers · Duke University

Biology Disciplines

Click to filter author papers

Cancer Biology· 1 Developmental Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Organism:Drosophila· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1

Frequent Co-Authors

Christian G. Cerda-SmithiD· 1 shared Chun‐Qing SongiD· 1 shared Dale A. RamsdeniD· 1 shared Dengfeng LiiD· 1 shared En-Zhi SheniD· 1 shared Fu YangiD· 1 shared Haley M. HutchinsoniD· 1 shared Huilin NiuiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperCancer Biology

Christian G. Cerda-SmithORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

BRCA1-A and LIG4 complexes mediate ecDNA biogenesis and cancer drug resistance

Oliver W. Chung, Shun Yao, Ling Wang, Fu Yang, Lauren Schier, Melissa Aldana, Christian G. Cerda-Smith, Haley M. Hutchinson, Kris C. Wood, Weijia Su, Mustafa Khasraw, Lee Zou, Dale A. Ramsden, ZZ Zhao Zhang

This study identifies BRCA1-A and LIG4 complexes as mediators of ecDNA biogenesis and shows their role in cancer drug resistance.

Proceedings of the National Academy of Sciences · Mar 11, 2026Peer-reviewedCancer Biology

Mammalian PIWI-piRNA-target complexes reveal features for broad and efficient target-silencing

Zhiqing Li, Zhenzhen Li, Yuqi Zhang, Lunni Zhou, Qikui Xu, Lili Li, Lin Zeng, Junchao Xue, Huilin Niu, Jing Zhong, Qilu Yu, Dengfeng Li, Miao Gui, Yongping Huang, Shikui Tu, , En-Zhi Shen

This study reveals structural and functional features of mammalian PIWI-piRNA-target complexes that enable efficient and broad target silencing.

Nature Structural & Molecular Biology · Apr 24, 2024Peer-reviewedMolecular Biology

Developmental retrotransposon activation primes host immunity for future viral-clearance

Lu Wang, Lauren Tracy, ZZ Zhao Zhang

The paper shows that Gypsy retrotransposon activation during Drosophila metamorphosis primes innate immunity, enhancing viral clearance in adult flies.

bioRxiv · Aug 23, 2020 · PreprintDevelopmental Biology